Jonn2 - 2017-10-10 01:58:21: comment4, www.sitelinks.info, 854, http://arc.asm.ca.gov/redirect.aspx?URL=https://www. A main strength of the current study was the use of a detailed interview method (CAMEEI) with an informed respondent to capture early childhood adversities. The study had, however, low statistical power overall due to the natural low prevalence rates for adolescents with CA also possessing short copies of the 5-HTTLPR allele.

Methodology and Principal Findings We used a sample of 238 adolescents from a community study characterised by the presence of the short allele of 5-HTTLPR (LL, LS, SS) and the presence or absence of exposure to CA before 6 years of age. We measured cognitive and emotional processing using a set of neuropsychological tasks selected predominantly from the CANTAB® battery. We found that adolescents homozygous for the short allele (SS) of 5-HTTLPR and exposed to CA were worse at classifying negative and neutral stimuli and made more errors in response to ambiguous negative feedback.

In addition, cognitive and emotional processing deficits were associated with diagnoses of anxiety and/or depressions. Citation: Owens M, Goodyer IM, Wilkinson P, Bhardwaj A, Abbott R, Croudace T, et al. (2012) 5-HTTLPR and Early Childhood Adversities Moderate Cognitive and Emotional Processing in Adolescence. PLoS ONE 7(11): e48482.

Editor: Andrew H. Kemp, University of Sydney, Australia Received: March 7, 2012; Accepted: October 2, 2012; Published: November 28, 2012 Copyright: © 2012 Owens et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: IMG, PW, TC, PBJ, and BJS are supported by programme and project grants from the Wellcome Trust (Grant no. 074296), MRC (UK) and NIHR (UK). TC held a Senior Research Fellowship from the Department of Health, UK during this study.

BJS is a member of the Behavioural and Clinical Neurosciences Institute, University of Cambridge. This work was completed within the NIHR Collaborations for Leadership in Applied Health Research and Care (CLAHRC) of which PBJ is Director and IMG and TC are the Adolescent Programme and Methods leaders respectively. The CLAHRC is hosted by the University of Cambridge and the Cambridge and Peterborough NHS Foundation Trust. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Free download pangya bonus pang hack programs for battle. Competing interests: BJS consults for Cambridge Cognition Ltd. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. Introduction Allelic variation in the promoter region of the serotonin transporter ( 5-HTTLPR), encoded by a single gene (SLC6A4), is partly responsible for regulating serotonergic (5-hydroxytryptamine, 5-HT) functions in the brain.